Mint 1

A multi-domain adaptor-protein that interacts with different neuronal proteins

General references Mint 1

Zhang W, Lilja L, Bark C, Berggren PO & Meister B (2004). Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells. Biochemical and Biophysical Research Communications 320: 717-21.

Leonoudakis D, Conti LR, Radeke CM, McGuire LM & Vandenberg CA (2004). A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Journal of Biological Chemistry 279: 19051-63.

Ho A, Morishita W, Hammer RE, Malenka RC & Sudhof TC (2003). A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proceedings of the National Academy of Sciences USA 100: 1409-14

Biederer T, Cao X, Südhof TC & Liu X (2002). Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. Journal of Neuroscience 22: 7340-51.

Tabuchi K, Biederer T, Butz S & Sudhof TC. (2002). CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. Journal of Neuroscience 22: 4264-73.

Okamoto M, Nakajima Y, Matsuyama T & Sugita M (2001). Amyloid precursor protein associates independently and collaboratively with PTB and PDZ domains of mint on vesicles and at cell membrane. Neuroscience 104: 653-65.

Mueller HT, Borg JP, Margolis B & Turner RS (2000). Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. Journal of Biological Chemistry 275: 39302-6.