Muscarinic Acetylcholine Receptor 2 (m-AChR-2)

A G protein-coupled acetylcholine receptor

General Information

The muscarinic acetylcholine receptors comprise 5 members (m1 - m5) and mediate many acetylcholine driven cellular actions such as adenylate cyclase inhibition, phosphoinositide degeneration and potassium channel mediation. They belong to a larger family of G protein-coupled receptors. Muscarinic acetylcholine receptor 2 has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release in the basal forebrain. It is also expressed in cardiac tissue where it is involved in mediation of bradycardia and a decrease in cardiac contractility.