Inositol 1, 4, 5 - trisphophate receptor (InsP3)

Triggers release of Ca²⁺ from intracellular stores

General Information

Inositol 1, 4, 5 - trisphophate InsP3 is an intracellular messenger that triggers release of Ca²⁺ from intracellular stores. InsP3 acts by binding to specific receptors localized to endoplasmic reticulum.
There are at least three types of InsP3 receptors, of which the type 1 receptor is the most abundant. All three receptors appear to be widely expressed. Highest levels of the type 1 InsP3 receptors are found in neurons, with very high expression in the Purkinje cells of the cerebellum.