IBA 1 (AIF 1)

A calcium binding protein specific for microglia

General Information

Ionized calcium-binding adaptor molecule 1 (IBA 1) or allograft inflammatory factor 1 (AIF 1) is an EF hand calcium binding protein which is expressed selectively in microglia/macrophages. Microglia are the smallest of the glial cell types in the central nervous system with cell bodies of only 2-5 µm in diameter.
IBA 1 expression has been suggested to be associated with the neuroinflammatory response and with transplant rejection.