GARP (LRRC 32)

An orphan receptor on T_reg-cells

References SySy GARP antibodies

Rappl G, Pabst S, Riemann D, Schmidt A, Wickenhauser C, Schütte W, Hombach AA, Seliger B, Grohé C & Abken H (2011). Regulatory T cells with reduced repressor capacities are extensively amplified in pulmonary sarcoid lesions and sustain granuloma formation. Clinical Immunology Apr 9, [Epub ahead of print]. clone 272G6; FACS

Probst-Kepper M, Geffers R, Kröger A, Viegas N, Erck C, Hecht HJ, Lünsdorf H, Roubin R, Moharregh-Khiabani D, Wagner K, Ocklenburg F, Jeron A, Garritsen H, Arstila TP, Kekäläinen E, Balling R, Hauser H, Buer J & Weiss S (2009). GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal of Cellular and Molecular Medicine 13(9B): 3343-57. clone 50G10; WB, clone 272G6; FACS

General references GARP

Pilat N, Baranyi U, Klaus C, Jaeckel E, Mpofu N, Wrba F, Golshayan D, Muehlbacher F & Wekerle T (2010). Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. American Journal of Transplantation 10: 751-62

Battaglia M & Roncarolo MG (2009). The Tregs' world according to GARP. European Journal of Immunology 39: 3296-300.

Wang R, Wan Q, Kozhaya L, Fujii H & Unutmaz D (2008). Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLos ONE 3(7): e2705.

Valencia X & Lipsky PE (2007). CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Nature Clinical Practice; Rheumatology 3: 619-26. Review