GARP (LRRC 32)
An orphan receptor on Treg-cells
General Information
Regulatory T-cells (Treg-cells) are involved in the homeostasis of immune reactions and tolerance. These specialized T-cells suppress auto-reactive cells and inhibit autoimmunity. Development and function of Treg-cells depend on the expression of the transcription factor FOX3P.The orphan receptor GARP, also referred to as LRRC 32, is exclusively found on Treg-cells upon stimulation with anti-CD3/IL-2 or anti-CD3/anti-CD28/IL-2. Additionally it has been shown, that ectopic GARP expression strongly induces FOXP3.
