GADs
Synthesizing GABA, the major inhibitory neurotransmitter in the central nervous system
References SySy GAD antibodies
Saliba RS, Gu Z, Yan Z & Moss SJ (2009). Blocking L-type voltage gated Ca2+ channels with dihydropyridines reduces gamma-aminobutyric acid type a receptor expression and synaptic inhibition. Journal of Biological Chemistry Sep 284: 32544-50. GAD 2 rabbit antibody; WBGeneral references GADs
Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J & Baekkeskov S (2008). A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. Journal of Cell Science 121 (Pt4): 437-49.Kinney JW, Davis CN, Tabarean I, Conti B, Bartfai T & Behrens MM (2006). A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons. Journal of Neuroscience 26: 1604-15.
Tamamaki N, Yanagawa Y, Tomioka R, Miyazaki J, Obata K & Kaneko T (2003). Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. Journal of Comparative Neurology 467: 60-79.
Kanaani J, Lissin D, Kash SF & Baekkeskov S (1999). The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65. Journal of Biological Chemistry 274: 37200-9.
Kim J, Richter W, Aanstoot HJ, Shi Y, Fu Q, Rajotte R, Warnock G & Baekkeskov S (1993). Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets. Diabetes 42: 1799-808.
Tillakaratne NJ, Erlander MG, Collard MW, Greif KF & Tobin AJ (1992). Glutamate decarboxylases in nonneural cells of rat testis and oviduct: differential expression of GAD65 and GAD67. Journal of Neurochemistry 58: 618-27.
Christgau S, Schierbeck H, Aanstoot HJ, Aagaard L, Begley K, Kofod H, Hejnaes K & Baekkeskov S (1991). Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. Journal of Biological Chemistry 266: 21257-64. no abstract available. Erratum in Journal of Biological Chemistry 266: 23516.
