Erd 2

KDEL receptor involved in retrograde Golgi-to-ER transport

General Information

Retrograde Golgi-to-ER transport by COP 1 coated vesicles serves the recycling of escaped ER-proteins that carry the C-terminal KDEL signal. The KDEL-receptor Erd 2 binds to this signal and retrieves it to the ER. Once returned the Erd 2-ligand complex dissociates and releases Erd 2 for additional recycling rounds.