Endophilin (SH3P4, SH3GL2)

An SH3 domain protein involved in clathrin mediated endocytosis

General Information

Endophilin, also referred to as SH3P4 and SH3GL2, is an SH3 domain protein involved in clathrin mediated synaptic vesicle recycling. It has been shown to recruite and to stabilize the polyphosphoinositide phosphatase synaptojanin at nerve terminals.
Recently the divergent C-terminal tail of VGLUT 1 has been reported to be a binding partner of Endophilin A1.