Endobrevin (VAMP8)

Endosomal fusion protein, member of the R-SNARE family

General Information

Endobrevin/VAMP8, a member of the SNARE family of proteins, is a relative of synaptobrevin that is involved in the fusion of early and late endosomes. Endobrevin is expressed in most mammalian cells but appears to be absent from neurons. The protein is predominantly localized to early and late endosomal membranes but is also found on other membranes and organelles involved in endocytic membrane traffic. In the fusion of late endosomes it forms SNARE complexes with syntaxin 7, syntaxin 8 and vti1b.