Claudin 11 (OSP)

An oligodendrocyte specific protein

General Information

Claudin 11, also known as Oligodendrocyte specific protein (OSP), is one of the most abundant components of CNS myelin where it locates to the interlamellar strands in myelin sheaths. To date more than 20 members of the claudin family have been identified. They are expressed in epithelial and endothelial cells in all tight junction bearing tissues. Claudins share a common transmembrane topology with 4 transmembrane spanning domains and two extracellular loops.