Botulinum neurotoxin (BoNT)

A toxin inhibiting neurotransmitter release

General references BoNT

Mahrhold S, Rummel A, Bigalke H, Davletov B & Binz T (2006). The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Letter 580: 2011-4.

Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R & Chapman ER (2006). SV2 Is the Protein Receptor for Botulinum Neurotoxin A. Science 312: 592-6.

Arndt JW, Chai Q, Christian T & Stevens RC (2006). Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 A Resolution: Repercussions for VAMP-2 Substrate Specificity. Biochemistry 45: 3255-62.

Chen S & Barbieri JT (2006). Unique substrate recognition by botulinum neurotoxins serotypes A and E. Journal of Biological Chemistry 281: 10906-11.

Rosales RL, Bigalke H & Dressler D (2006). Pharmacology of botulinum toxin: differences between type A preparations. European Journal of Neurology Suppl 1: 2-10.

Gessler F, Hampe K & Bohnel H (2005). Sensitive detection of botulinum neurotoxin types C and D with an immunoaffinity chromatographic column test. Applied and Environmental Microbiology 71: 7897-903.

Smith TJ, Lou J, Geren IN, Forsyth CM, Tsai R, Laporte SL, Tepp WH, Bradshaw M, Johnson EA, Smith LA & Marks JD (2005). Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infection and Immunity 73: 5450-7.

Ferracci G, Miquelis R, Kozaki S, Seagar M & Leveque C (2005). Synaptic vesicle chips to assay botulinum neurotoxins. Biochemical Journal 391(Pt 3): 659-66.

Breidenbach MA & Brunger AT (2005). New insights into clostridial neurotoxin-SNARE interactions. Trends in Molecular Medicine 11: 377-81. Review

Montecucco C & Molgo J (2005). Botulinal neurotoxins: revival of an old killer. Current Opinion in Pharmacology 5: 274-9. Review

Agarwal R, Eswaramoorthy S, Kumaran D, Binz T & Swaminathan S (2004). Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212→Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway. Biochemistry 43: 6637-44.