AP 180

A synaptic protein involved in clathrin mediated endocytosis

References SySy AP 180 antibodies

Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Üçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M & Sommer C (2010). Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 188: 3166-80. affinity purified rabbit antibody; ICC

General references AP 180

Bao H, Daniels RW, MacLeod GT, Charlton MP, Atwood HL & Zhang B (2005). AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis. Journal of Neurophysiology 94: 1888-903.

Yao PJ, Petralia RS, Bushlin I, Wang Y & Furukawa K (2005). Synaptic distribution of the endocytic accessory proteins AP180 and CALM. Journal of Comparative Neurology 481: 58-69.

Yao PJ, Coleman PD & Calkins DJ (2002). High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons. Journal of Comparative Neurology 447: 152-62.

Kalthoff C, Alves J, Urbanke C, Knorr R & Ungewickell EJ (2002). Unusual structural organization of the endocytic proteins AP180 and epsin 1. Journal of Biological Chemistry 277: 8209-16.

Yao PJ, Morsch R, Callahan LM & Coleman PD (1999). Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry. Neuroscience 94: 389-94.

Hao W, Luo Z, Zheng L, Prasad K & Lafer EM (1999). AP180 and AP-2 interact directly in a complex that cooperatively assembles clathrin. Journal of Biological Chemistry 274: 22785-94.

Morris SA, Schroder S, Plessmann U, Weber K & Ungewickell E (1993). Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site. EMBO Journal 12: 667-75.

Prasad K & Lippoldt RE (1988). Molecular characterization of the AP180 coated vesicle assembly protein. Biochemistry 27: 6098-104.