Abeta (Beta-APP, ABPP)

A major component of neuritic plaques in Alzheimer's disease

References SySy Abeta antibodies

Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, Kumar S, Multhaup G, Walter J, Ingelsson M, Degerman-Gunnarsson M, Kalimo H, Huitinga I, Lannfelt L & Bayer TA (2010). Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis. Journal of Biological Chemistry 285: 41517-24. Clone NT78; ELISA

Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU & Bayer TA (2010). Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate abeta formation, induces behavioral deficits and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice. Journal of Biological Chemistry, Dec 10. [Epub ahead of print] Clone NT78; IHC

General references Abeta

Marcello A, Wirths O, Schneider-Axmann T, Degerman-Gunnarsson M, Lannfelt L & Bayer TA (2009). Circulating immune complexes of Abeta and IgM in plasma of patients with Alzheimer's disease. Journal of Neural Transmission 116: 913-20.

Baril L, Nicolas L, Croisile B, Crozier P, Hessler C, Sassolas A, McCormick JB & Trannoy E (2004). Immune response to Abeta-peptides in peripheral blood from patients with Alzheimer's disease and control subjects. Neuroscience Letters 355: 226-30.

Bayer TA, Schäfer S, Simons A, Kemmling A, Kamer T, Tepest R, Eckert A, Schüssel K, Eikenberg O, Sturchler-Pierrat C, Abramowski D, Staufenbiel M & Multhaup G (2003). Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Biological Proceedings of the National Academy of Scienes USA 100: 14187-92.

Holtzman DM (2002). Abeta conformational change is central to Alzheimer's disease. Neurobiology of Aging 23: 1085-8. no abstract available

Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F & Cole G (1996). Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274: 99-102.

Wood SJ, Maleeff B, Hart T & Wetzel R (1996). Physical, morphological and functional differences between ph 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta. Journal of Molecular Biology 256: 870-7.

Kuo YM, Emmerling MR, Vigo-Pelfrey C, Kasunic TC, Kirkpatrick JB, Murdoch GH, Ball MJ & Roher AE (1996). Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains. Journal of Biological Chemistry 271: 4077-81.